Mutational Profiling Can Establish Clonal or Independent Origin in Synchronous Bilateral Breast and Other Tumors.

Published in PLoS ONE

Epidemiology, pathogenesis, and genetics of acoustic tumors.

Published in Otolaryngologic Clinics of North America

This article reviews the epidemiology of both unilateral and bilateral (NF-2) acoustic tumors. The growth rate of acoustic tumors is examined from a clinical, radiographic, and laboratory perspective. The anatomic, histologic, and biochemical considerations as well as the influences of sex hormones on acoustic tumor formation are reviewed. Also pre...

Evolutionarily conserved sequences on human chromosome 21.

Published in Genome Research

Comparison of human sequences with the DNA of other mammals is an excellent means of identifying functional elements in the human genome. Here we describe the utility of high-density oligonucleotide arrays as a rapid approach for comparing human sequences with the DNA of multiple species whose sequences are not presently available. High-density arr...

Multi-species sequence comparison: the next frontier in genome annotation.

Published in Genome Biology

Multi-species comparisons of DNA sequences are more powerful for discovering functional sequences than pairwise DNA sequence comparisons. Most current computational tools have been designed for pairwise comparisons, and efficient extension of these tools to multiple species will require knowledge of the ideal evolutionary distance to choose and the...