Effective filtering strategies to improve data quality from population-based whole exome sequencing studies
Published in BMC Bioinformatics
BackgroundGenotypes generated in next generation sequencing studies contain errors which can significantly impact the power to detect signals in common and rare variant association tests. These genotyping errors are not explicitly filtered by the standard GATK Variant Quality Score Recalibration (VQSR) tool and thus remain a source of errors in who...
