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miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1.... PDF available through Get Fulltext Research

Mraz, Marek Chen, Liguang Rassenti, Laura Z Ghia, Emanuela M Li, Hongying Jepsen, Kristen Smith, Erin N Messer, Karen Frazer, Kelly A Kipps, Thomas J ...

Published in Blood

We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but with leukemia cell expression levels that varied among patients. CLL cells that expressed ΞΆ-chain-associated protein of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each had ...

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