Alakus, Hakan Yost, Shawn E Woo, Brian French, Randall Lin, Grace Y Jepsen, Kristen Frazer, Kelly A Lowy, Andrew M Harismendy, Olivier
Published in
Journal of Translational Medicine
BackgroundMalignant mesothelioma (MM) arises from mesothelial cells that line the pleural, peritoneal and pericardial surfaces. The majority of MMs are pleural and have been associated with asbestos exposure. Previously, pleural MMs have been genetically characterized by the loss of BAP1 (40-60%) as well as loss of NF2 (75%) and CDKN2A (60%). The r...
Crews, Leslie A Jiang, Qingfei Zipeto, Maria A Lazzari, Elisa Court, Angela C Ali, Shawn Barrett, Christian L Frazer, Kelly A Jamieson, Catriona HM
Published in
Journal of Translational Medicine
BackgroundDeregulation of RNA editing by adenosine deaminases acting on dsRNA (ADARs) has been implicated in the progression of diverse human cancers including hematopoietic malignancies such as chronic myeloid leukemia (CML). Inflammation-associated activation of ADAR1 occurs in leukemia stem cells specifically in the advanced, often drug-resistan...
