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BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma PDF available through Get Fulltext Research

Alakus, Hakan Yost, Shawn E Woo, Brian French, Randall Lin, Grace Y Jepsen, Kristen Frazer, Kelly A Lowy, Andrew M Harismendy, Olivier

Published in Journal of Translational Medicine

BackgroundMalignant mesothelioma (MM) arises from mesothelial cells that line the pleural, peritoneal and pericardial surfaces. The majority of MMs are pleural and have been associated with asbestos exposure. Previously, pleural MMs have been genetically characterized by the loss of BAP1 (40-60%) as well as loss of NF2 (75%) and CDKN2A (60%). The r...

An RNA editing fingerprint of cancer stem cell reprogramming PDF available through Get Fulltext Research

Crews, Leslie A Jiang, Qingfei Zipeto, Maria A Lazzari, Elisa Court, Angela C Ali, Shawn Barrett, Christian L Frazer, Kelly A Jamieson, Catriona HM

Published in Journal of Translational Medicine

BackgroundDeregulation of RNA editing by adenosine deaminases acting on dsRNA (ADARs) has been implicated in the progression of diverse human cancers including hematopoietic malignancies such as chronic myeloid leukemia (CML). Inflammation-associated activation of ADAR1 occurs in leukemia stem cells specifically in the advanced, often drug-resistan...

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