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Elucidating the role of 8q24 in colorectal cancer.

Harismendy, Olivier Frazer, Kelly A

Published in Nature genetics

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.

Kooner, Jaspal S Chambers, John C Aguilar-Salinas, Carlos A Hinds, David A Hyde, Craig L Warnes, Gregory R Gómez Pérez, Francisco J Frazer, Kelly A Elliott, Paul Scott, James ...

Published in Nature genetics

We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a nonsynonymous SNP (rs3812316, G771C, Gln241His) in MLXIPL with plasma triglyceride levels (combined P = 1.4 x 10(-10)). MLXIPL coordinates t...

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