Zhou, Dan Udpa, Nitin Gersten, Merril Visk, DeeAnn W Bashir, Ali Xue, Jin Frazer, Kelly A Posakony, James W Subramaniam, Shankar Bafna, Vineet
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Through long-term laboratory selection (over 200 generations), we have generated Drosophila melanogaster populations that tolerate severe, normally lethal, levels of hypoxia. Because of initial experiments suspecting genetic mechanisms underlying this adaptation, we compared the genomes of the hypoxia-selected flies with those of controls using dee...
Kl, Mcnally Kl, Childs R, Bohnert Rm, Davidson K, Zhao Vj, Ulat G, Zeller Rm, Clark Dr, Hoen Te, Bureau
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Published in
Proceedings of the National Academy of Sciences
Rice, the primary source of dietary calories for half of humanity, is the first crop plant for which a high-quality reference genome sequence from a single variety was produced. We used resequencing microarrays to interrogate 100 Mb of the unique fraction of the reference genome for 20 diverse varieties and landraces that capture the impressive gen...
Jiang, Qingfei Crews, Leslie A Barrett, Christian L Chun, Hye-Jung Court, Angela C Isquith, Jane M Zipeto, Maria A Goff, Daniel J Minden, Mark Sadarangani, Anil
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Published in
Proceedings of the National Academy of Sciences of the United States of America
The molecular etiology of human progenitor reprogramming into self-renewing leukemia stem cells (LSC) has remained elusive. Although DNA sequencing has uncovered spliceosome gene mutations that promote alternative splicing and portend leukemic transformation, isoform diversity also may be generated by RNA editing mediated by adenosine deaminase act...
